Sodium lauroyl sarcosinate (INCI), also known as sarkosyl , is an ionic surfactant derived from sarcosin used as a foaming agent and cleanser in shampoo, shaving foam, toothpaste, and foam washing products. In molecular biology experiments, sarkosyl is used to inhibit the initiation of DNA transcription.
This surfactant is amphiphilic because of 12-carbon hydrophobic chains (lauroyl) and hydrophilic carboxylates. Since the nitrogen atoms in the amide relationship, nitrogen is inactive and pH is neutral in all aqueous solutions regardless of pH. The carboxylate has a pKa of about 3.6 and is therefore negatively charged in a pH solution greater than about 5.5.
Vesicles that are sensitive to pH can be prepared using this surfactant with cationic amphiphiles or other insoluble water such as 1-dekanol.
The addition of a mixture of equal parts of sodium lauroyl sarcosinate and non-ionic sorbitan monolauric surfactant (S20) to water causes the formation of micellar aggregates, although the surfactant does not form micelles when present alone. Such aggregates can help carry other small molecules, such as drugs, through the skin.
Video Sodium lauroyl sarcosinate
In culture
Sodium lauroyl sarcosinate was sold as a special ingredient called 'Gardol' in Colgate Dental Cream (toothpaste) during the 1950s to mid-1960s in the US and mid-1970s in France. Current use as preventive toothpaste is in Arm & amp; Toothpaste hammer.
Maps Sodium lauroyl sarcosinate
References
- AmbÃÆ'¼hl, M; F. Bangerter; P.L. Luisi; P. Skrobal; H.J. Watzke (1993). "The configuration changes that accompany the vesiculation of a single-chip mixed amphiphiles". Langmuir . 9 : 36-38. doi: 10.1021/la00025a011.
- Ghosh, S; J.Dey (2011). J. Colloid Interface Sci . 358 : 208-216.
External links
- "Occupational Allergic Contact Dermatitis From Sodium Lauroyl Sarcosinate in Liquid Soap," Zemtsov, Alexander MD, MSC; Fett, Deborah MD, Dermatitis , June 2005, Volume 16, Issue 2, page 97
Source of the article : Wikipedia
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